ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression.
作者信息
Allorge D, Hamdan R, Broly F, Libersa C, Colombel J-F
出版信息
Gut. 2005 Apr;54(4):565. doi: 10.1136/gut.2004.055947.
Abstract
摘要
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ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression.
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本文引用的文献
1
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).
Pharmacogenetics. 2004 Mar;14(3):181-7. doi: 10.1097/00008571-200403000-00006.
2
Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.
Hum Genet. 2002 Oct;111(4-5):360-7. doi: 10.1007/s00439-002-0798-z. Epub 2002 Aug 15.
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Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.
Gastroenterology. 2000 Jun;118(6):1025-30. doi: 10.1016/s0016-5085(00)70354-4.
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