Bubała Halina, Sońta-Jakimczyk Danuta, Janik-Moszant Anna, Szczepański Tomasz, Tomaszewska Renata, Drybańska Bozena, Sierantowicz-Zdaniewicz Urszula, Frankiewicz Ewa
Klinika Pediatrii, Hematologii i Onkologii Dzieciecej Slaskiej AM w Zabrzu.
Pol Merkur Lekarski. 2004 Nov;17(101):500-2.
We present two patients with chronic myeloid leukemia and hyperleukocytosis above 350 x 10(9)/l causing the symptoms of pulmonary leukostasis. Therapeutic leukapheresis procedures with concomitant chemotherapy were initiated within 12 hours from the diagnosis. After the therapy commencement the general condition of the patients systematically improved and leukocytosis gradually decreased from the second day of treatment with disappearance of pulmonary leukostasis symptoms. Thanks to application of such treatment procedures during the cytoreductive period, severe complications related to leukostasis could be prevented.
我们报告了两名慢性髓性白血病患者，其白细胞增多超过350×10⁹/L，导致肺部白细胞淤滞症状。在诊断后12小时内启动了伴有化疗的治疗性白细胞单采程序。治疗开始后，患者的一般状况系统性改善，白细胞增多从治疗第二天起逐渐下降，肺部白细胞淤滞症状消失。由于在细胞减灭期应用了此类治疗程序，与白细胞淤滞相关的严重并发症得以预防。
