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一种针对接受Milligan-Morgan痔切除术患者的无痛治疗方法。

A painless treatment for patients undergoing Milligan-Morgan haemorrhoidectomy.

作者信息

Di Vita G, Patti R, Arcara M, Petrone R, Davì V, Leo P

机构信息

Università degli Studi di Palermo, Dipartimento di Discipline Chirurgiche ed Oncologiche, U.O. di Chirurgia Generale, Endoscopica, Diagnostica ed Interventistica, Italy.

出版信息

Ann Ital Chir. 2004 Jul-Aug;75(4):471-4; discussion 474-5.

Abstract

BACKGROUND

Postoperative pain associated with Milligan Morgan haemorrhoidectomy (MMH) remains problematic. Most patients complaint a severe pain on defecation and in the 1st postoperative week because of secondary infection and sphincter spasm. We studied the effect of metronidazole, lactulose and glyceryl-trinitrate on pain after MMH.

METHOD

Thirty patients were randomly assigned to two groups. The 1st received a treatment with oral laxative (lactulose 66.7%) metronidazole and a topical glyceryl-trinitrate ointment at 0.2% both pre and postoperative; the 2nd received a placebo at the same dosage. The amount of pain in the 1st week and at the time of two defecation, postoperative analgesic requirement and time to return to normal activities were documented.

RESULTS

A significant differences in the score pain on 2nd and 3rd day and on the 1st two defecation were observed among group. Analgesic consumption was highest in the placebo group.

CONCLUSION

The treatment with lactulose, metronidazole and topic glyceryl-trinitrate in patients undergoing MMH, seems to reduce secondary pain and increase patients satisfaction and earlier return to work with improvement of cost and benefit.

摘要

背景

与Milligan Morgan痔切除术(MMH)相关的术后疼痛仍然是个问题。大多数患者因继发感染和括约肌痉挛在排便时及术后第一周主诉严重疼痛。我们研究了甲硝唑、乳果糖和硝酸甘油对MMH术后疼痛的影响。

方法

30例患者被随机分为两组。第一组在术前和术后均接受口服泻药(66.7%乳果糖)、甲硝唑以及局部应用0.2%硝酸甘油软膏的治疗;第二组接受相同剂量的安慰剂治疗。记录第一周及两次排便时的疼痛程度、术后镇痛需求以及恢复正常活动的时间。

结果

两组在术后第二天和第三天以及最初两次排便时的疼痛评分存在显著差异。安慰剂组的镇痛药物消耗量最高。

结论

对于接受MMH的患者,乳果糖、甲硝唑和局部应用硝酸甘油的治疗似乎能减轻继发性疼痛,提高患者满意度,并能更早恢复工作,改善成本效益。

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