Al-Mulhim Abdulrahman S, Ali Adel M, Al-Masuod Nabil, Alwahidi Adel
Department of Surgery, King Fahad Hospital, PO Box 1164, Hofuf, Al-Hassa 31982, Kingdom of Saudi Arabia.
Saudi Med J. 2006 Oct;27(10):1538-41.
To compare the effect of metronidazole on post conventional hemorrhoidectomy pain in patients with third and fourth degree hemorrhoids.
Two hundred consecutive patients admitted in King Fahad Hospital, Hofuf, Saudi Arabia between June 2002 and May 2004 for surgical treatment of 3rd and 4th degree hemorrhoids were randomly assigned into 2 groups. In Group 1 (100 patients) pre and postoperative metronidazole was used and in Group 2 (100 patients) no medications were given. All patients received castor oil from 2 days before surgery and lactulose after surgery for 2 weeks. Patients were discharged home when free of pain.
Patients in group 1 had significantly less pain than those in the second group. Hospital stay and time to first bowel motion were not significantly different between both groups and, early and late complications appear similar. Return to normal activity was significantly shorter in the metronidazole group.
Prophylactic metronidazole in Milligan-Morgan hemorrhoidectomy is associated with less pain and earlier return to normal activity.
比较甲硝唑对Ⅲ、Ⅳ度痔疮患者传统痔切除术后疼痛的影响。
2002年6月至2004年5月在沙特阿拉伯胡富夫法赫德国王医院连续收治的200例因Ⅲ、Ⅳ度痔疮接受手术治疗的患者被随机分为两组。第1组（100例患者）术前和术后使用甲硝唑，第2组（100例患者）不给予任何药物。所有患者术前2天服用蓖麻油，术后服用乳果糖2周。患者无痛时出院。
第1组患者的疼痛明显少于第2组。两组患者的住院时间和首次排便时间无显著差异，早期和晚期并发症相似。甲硝唑组恢复正常活动的时间明显缩短。
在Milligan-Morgan痔切除术中预防性使用甲硝唑可减轻疼痛并使患者更早恢复正常活动。
