Mitsutake Gen, Otsuka Kuniaki, Oinuma Sachiko, Ferguson Ian, Cornélissen Germaine, Wanliss James, Halberg Franz
Division of Neurocardiology and Chronoecology, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan.
Biomed Pharmacother. 2004 Oct;58 Suppl 1:S20-7. doi: 10.1016/s0753-3322(04)80004-0.
The aim of this study was to determine whether an artificial magnetic field with an amplitude and frequency equivalent to those of geomagnetic pulsations during geomagnetic storms could affect physiology and psychology. Three healthy volunteers wore anambulatory BP monitor and an ECG recorder around the clock for 12 consecutive weekends in Winnipeg, Manitoba, Canada. In a room shielded against ELF and VLF waves, they were exposed for 8 hours per week to either a 50 nT 0.0016 Hz or a sham magnetic field at one of six circadian stages. Real exposure randomly alternated with sham exposure. They provided saliva and recorded mood and reaction time every 4 hours while awake. Systolic (S) and diastolic (D) blood pressure (BP), and heart rate (HR) were recorded every 30 minutes. Spectral analysis of HR variability (HRV) was performed using the maximum entropy method and a complex demodulation method. For these variables, daily means were compared between real and sham exposure, using paired t-tests. Their circadian MESOR, amplitude, and acrophase were analyzed and summarized using single cosinor and population-mean cosinor. Circadian rhythms were demonstrated for HR, SBP, DBP for sham exposure, salivary flow rate, positive affect, vigor, and subjective alertness (p < 0.001, -0.02). One participant showed higher HR, lower LF, HF, and VLF powers, and a steeper power-law slope (p < 0.005, -0.0001) in an early night exposure to the real magnetic field, but not in other circadian stages. There was no significant difference between circadian responses to real and sham exposure in any variable at any circadian stage.
本研究的目的是确定在磁暴期间,幅度和频率与地磁脉动相当的人工磁场是否会影响生理和心理。三名健康志愿者在加拿大马尼托巴省温尼伯市连续12个周末全天佩戴动态血压监测仪和心电图记录仪。在一个屏蔽了极低频和甚低频波的房间里,他们在六个昼夜节律阶段中的一个阶段,每周接受8小时的50 nT 0.0016 Hz磁场或假磁场照射。实际照射与假照射随机交替。他们在清醒时每4小时提供唾液并记录情绪和反应时间。每30分钟记录收缩压(S)和舒张压(D)以及心率(HR)。使用最大熵方法和复解调方法对心率变异性(HRV)进行频谱分析。对于这些变量,使用配对t检验比较实际照射和假照射之间的每日平均值。使用单余弦法和总体均值余弦法分析并总结他们的昼夜节律中值、振幅和峰值相位。假照射的HR、SBP、DBP、唾液流速、积极情绪、活力和主观警觉性呈现出昼夜节律(p < 0.001, -0.02)。一名参与者在夜间早期暴露于实际磁场时,HR较高,低频、高频和甚低频功率较低,功率律斜率较陡(p < 0.005, -0.0001),但在其他昼夜节律阶段未出现这种情况。在任何昼夜节律阶段,任何变量对实际照射和假照射的昼夜反应之间均无显著差异。
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