[Sequential changes of specific IgE, IgG4 antibodies and the development of allergic diseases in the first year of life].

Thirty infants who had siblings with major allergy were prospectively followed up to 12 months. Among 15 infants, in whom egg and milk were eliminated by the mother during third trimester and 12 months after birth, three infants developed food allergy. But, among 15 infants without any elimination either by the mother or the infant, 7 infants developed food allergy though this was not statistically significant. Among ten cases with food allergy, eight developed the symptoms during first six months. There were no correlations between allergic symptoms and Total IgE. Also, specific IgG4 did not show significant correlation with specific IgE and allergic symptoms except in several cases. Even though there was no significant decrease of food allergy by elimination of egg and milk during third trimester and 12 months after birth, elimination of egg and milk during that period give some benefit to the infant with strongly positive family history of major allergy under the close observation for growth and development of the infant.