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[肝脏与风湿病]

[Liver and rheumatism].

作者信息

Wiegard C, Lohse A W

机构信息

I. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

出版信息

Z Rheumatol. 2005 Feb;64(1):26-31. doi: 10.1007/s00393-005-0701-0.

Abstract

There are multiple relations between rheumatic diseases and the liver, nevertheless the liver is extremely rare involved in rheumatic diseases. "Elevated liver enzymes" are quite often found in patients who are under the medication with immunosuppressive drugs or/and non-steroidal antirheumatics. The most frequent cause for "elevated liver enzymes" are toxic and allergic side effects of drugs; however, in rare cases it might be extremely helpful to examine, whether an independent liver disease exists. Underlying liver diseases which might be associated with the rheumatic disorder or exist accidentally may change the therapeutic management of the patient. If the liver disease present can cause the rheumatic disorder (e. g. virus-induced vasculitis, hemochromatosis), a specific hepatological therapy should precede the immunosuppression.

摘要

风湿性疾病与肝脏之间存在多种关联,然而肝脏极少受累于风湿性疾病。在使用免疫抑制药物或/和非甾体类抗风湿药物治疗的患者中,经常会发现“肝酶升高”。“肝酶升高”最常见的原因是药物的毒性和过敏副作用;然而,在罕见情况下,检查是否存在独立的肝脏疾病可能会非常有帮助。可能与风湿性疾病相关或偶然存在的潜在肝脏疾病可能会改变患者的治疗管理。如果存在的肝脏疾病可导致风湿性疾病(例如病毒感染引起的血管炎、血色素沉着症),则在进行免疫抑制之前应先进行特定的肝病治疗。

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