Lortholary O, Sitbon K, Dromer F
Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Institut Pasteur, Paris, France.
Clin Microbiol Infect. 2005 Apr;11(4):296-300. doi: 10.1111/j.1469-0691.2005.01074.x.
Tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, -8 and-10 and soluble TNF receptor II (sTNFR II) levels were measured at baseline, and after antifungal therapy for 2 weeks and 3 months, in plasma from 75 human immunodeficiency virus (HIV)-positive and 14 HIV-negative patients with cryptococcosis, and in plasma from 14 HIV-positive controls. At baseline, TNF-alpha, IL-6 and sTNFR II levels, and cryptococcal antigen titres, were increased in patients with fungaemia compared to controls (p < 0.02). The mediator levels were not influenced by the severity of the disease or subsequent death, but sTNFR II and IL-10 levels were reduced, together with virus load, in patients receiving anti-retroviral agents (p < 0.01). During antifungal therapy, sTNFR II levels decreased (p 0.003) in parallel with the virus load and with an increase in CD4 T-cell numbers.
在75例人类免疫缺陷病毒（HIV）阳性和14例HIV阴性的隐球菌病患者以及14例HIV阳性对照者的血浆中，于基线时、抗真菌治疗2周和3个月后，检测肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6、-8和-10以及可溶性TNF受体II（sTNFR II）水平。与对照组相比，基线时真菌血症患者的TNF-α、IL-6和sTNFR II水平以及隐球菌抗原滴度升高（p<0.02）。介质水平不受疾病严重程度或随后死亡的影响，但接受抗逆转录病毒药物治疗的患者中，sTNFR II和IL-10水平以及病毒载量降低（p<0.01）。在抗真菌治疗期间，sTNFR II水平与病毒载量以及CD4 T细胞数量增加平行下降（p=0.003）。
