迷走神经活动在人体对去氧肾上腺素心血管反应中的作用。
Role of vagal activity in the cardiovascular responses to phenylephrine in man.
作者信息
Levine M A, Leenen F H
机构信息
Hypertension Unit, University of Ottawa Heart Institute, Ontario, Canada.
出版信息
Br J Clin Pharmacol. 1992 Mar;33(3):333-6. doi: 10.1111/j.1365-2125.1992.tb04047.x.
Abstract
The effects of phenylephrine on blood pressure (BP), left ventricular function and total peripheral resistance (TPR) were evaluated in six normotensive male volunteers before and after vagal blockade with atropine. Before atropine, phenylephrine dose-related increased TPR, systolic and diastolic BP and decreased cardiac output by decreases in both stroke volume and heart rate. Post-atropine, the BP (but not TPR) responses to phenylephrine were markedly potentiated, related to an increase in stroke volume despite the higher afterload. Thus vagal tone may regulate cardiac output via effects on both heart rate and venous return.
摘要
在六名血压正常的男性志愿者中，研究了在使用阿托品进行迷走神经阻滞前后，去氧肾上腺素对血压（BP）、左心室功能和总外周阻力（TPR）的影响。在使用阿托品之前，去氧肾上腺素剂量依赖性地增加TPR、收缩压和舒张压，并通过降低每搏量和心率来降低心输出量。使用阿托品后，去氧肾上腺素引起的血压（而非TPR）反应显著增强，这与尽管后负荷较高但每搏量增加有关。因此，迷走神经张力可能通过对心率和静脉回流的影响来调节心输出量。
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