Turner Gordon M, Zacharakis Giannis, Soubret Antoine, Ripoll Jorge, Ntziachristos Vasilis
Laboratory for Bio-optics and Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Opt Lett. 2005 Feb 15;30(4):409-11. doi: 10.1364/ol.30.000409.
We present the first, to our knowledge, experimental images of complex-shaped phantoms embedded in diffuse media by use of optical tomography. Imaging is based on a complete-angle projection tomographic technique that utilizes transmitted early photons. Results are contrasted with measurements obtained at later gates as well as pseudocontinuous-wave data. The scanning system developed employs noncontact illumination and detection technologies that allow for high spatial sampling of transmitted photons. Combining this system with complete-angle illumination is found to be an important strategy toward improved imaging performance, resulting in a better-posed inversion problem. The appropriateness of reconstruction algorithms similar to those employed in x-ray computed tomography are showcased, and suggestions for model improvements are provided.
据我们所知,我们首次展示了通过光学层析成像技术对嵌入漫射介质中的复杂形状体模进行的实验图像。成像基于一种利用透射早期光子的全角度投影层析技术。将结果与在较晚时间门获得的测量结果以及伪连续波数据进行了对比。所开发的扫描系统采用非接触照明和检测技术,能够对透射光子进行高空间采样。发现将该系统与全角度照明相结合是提高成像性能的一项重要策略,可导致一个更适定的反演问题。展示了与X射线计算机断层扫描中使用的算法类似的重建算法的适用性,并提供了模型改进建议。