McConnell K John, Newgard Craig D, Mullins Richard J, Arthur Melanie, Hedges Jerris R
Center for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, OR, USA.
Health Serv Res. 2005 Apr;40(2):435-57. doi: 10.1111/j.1475-6773.2005.00366.x.
To determine whether head-injured patients transferred to level I trauma centers have reduced mortality relative to transfers to level II trauma centers.
DATA SOURCE/STUDY SETTING: Retrospective cohort study of 542 patients with head injury who initially presented to 1 of 31 rural trauma centers in Oregon and Washington, and were transferred from the emergency department to 1 of 15 level I or level II trauma centers, between 1991 and 1994.
A bivariate probit, instrumental variables model was used to estimate the effect of transfer to level I versus level II trauma centers on 30-day postdischarge mortality. Independent variables included age, gender, Injury Severity Scale (ISS), other indicators of injury severity, and a dichotomous variable indicating transfer to a level I trauma center. The differential distance between the nearest level I and level II trauma centers was used as an instrument.
Patients transferred to level I trauma centers differ in unmeasured ways from patients transferred to level II trauma centers, biasing estimates based on standard statistical methods. Transfer to a level I trauma center reduced absolute mortality risk by 10.1% (95% confidence interval 0.3%, 22.2%) compared with transfer to level II trauma centers.
Patients with severe head injuries transferred from rural trauma centers to level I centers are likely to have improved survival relative to transfer to level II centers.
确定与转至二级创伤中心的头部受伤患者相比,转至一级创伤中心的患者死亡率是否降低。
数据来源/研究背景:对1991年至1994年间最初在俄勒冈州和华盛顿州的31家农村创伤中心之一就诊,后从急诊科转至15家一级或二级创伤中心之一的542例头部受伤患者进行回顾性队列研究。
采用双变量概率单位工具变量模型来估计转至一级创伤中心与二级创伤中心对出院后30天死亡率的影响。自变量包括年龄、性别、损伤严重程度评分(ISS)、其他损伤严重程度指标,以及一个表明转至一级创伤中心的二分变量。将最近的一级和二级创伤中心之间的差异距离用作工具变量。
转至一级创伤中心的患者与转至二级创伤中心的患者在一些无法测量的方面存在差异,这会使基于标准统计方法的估计产生偏差。与转至二级创伤中心相比,转至一级创伤中心可使绝对死亡风险降低10.1%(95%置信区间0.3%,22.2%)。
与转至二级中心相比,从农村创伤中心转至一级中心的重度头部受伤患者可能生存率更高。