Thunell Louise, Stadberg Elisabeth, Milsom Ian, Mattsson Lars-Ake
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden.
Acta Obstet Gynecol Scand. 2005 Apr;84(4):395-401. doi: 10.1111/j.0001-6349.2005.00725.x.
To study changes in: (i) the prevalence of hormone-replacement therapy (HRT) and (ii) women's attitudes and knowledge about the climacteric. Design. Cross-sectional comparison was performed on two populations of women both aged 46-62 years and resident in the same urban Swedish population over a period of 6 years.
In 1992, a random sample of 5990 women, from five birth cohorts, 46, 50, 54, 58, and 62 years in the city of Göteborg, were assessed using a postal questionnaire technique. In 1998, the same technique was used and a similar questionnaire was sent to another cohort of women (n=5411) of the same ages, resident in the city of Göteborg. The overall response rate was 76%. Information was obtained regarding climacteric symptoms, HRT use, and attitudes and knowledge.
The prevalence of HRT use with medium-potency estrogens had increased from 13% (1992) to 31% (1998). The highest prevalence was reported in women 54 years of age (46%). The most common reasons why women started HRT were: hot flushes and sweats, depression/irritability, sleeping disturbances, and vaginal dryness. Forty-four percent of the women in this study were prepared to consider extended HRT if the treatment was free from withdrawal bleedings (35%, 1992). Eighty percent believed that the risk of osteoporosis decreased during HRT use (61%, 1992) and 68% thought that the risk of breast cancer increased (58%, 1992).
A marked increase in the use of HRT was reported between 1992 and 1998. Women's attitudes to HRT were more positive in 1998 compared to 1992. Knowledge about HRT among women had increased during the same 6-year period.
研究以下方面的变化:(i)激素替代疗法(HRT)的使用率;(ii)女性对更年期的态度和认识。设计:对居住在瑞典同一城市、年龄均在46 - 62岁的两组女性人群进行了为期6年的横断面比较。
1992年,采用邮寄问卷调查技术对哥德堡市5个出生队列中年龄分别为46、50、54、58和62岁的5990名女性进行随机抽样评估。1998年,使用相同技术,向居住在哥德堡市的另一组相同年龄的女性(n = 5411)发送了类似问卷。总体回复率为76%。获取了有关更年期症状、HRT使用情况以及态度和认识方面的信息。
使用中效雌激素的HRT使用率从1992年的13%增至1998年的31%。54岁女性的使用率最高(46%)。女性开始使用HRT的最常见原因是:潮热和盗汗、抑郁/易怒、睡眠障碍以及阴道干燥。本研究中44%的女性表示,如果治疗无撤退性出血,她们愿意考虑延长HRT使用时间(1992年为35%)。80%的女性认为HRT使用期间骨质疏松风险降低(1992年为61%),68%的女性认为乳腺癌风险增加(1992年为58%)。
据报告,1992年至1998年间HRT的使用显著增加。与1992年相比,1998年女性对HRT的态度更为积极。在同一6年期间,女性对HRT的认识有所提高。