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科学证据改变处方实践——1996年和2003年瑞典妇科医生对更年期管理及激素替代疗法使用情况的比较。

Scientific evidence changes prescribing practice--a comparison of the management of the climacteric and use of hormone replacement therapy among Swedish gynaecologists in 1996 and 2003.

作者信息

Thunell Louise, Milsom Ian, Schmidt Johanna, Mattsson Lars-Ake

机构信息

Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden.

出版信息

BJOG. 2006 Jan;113(1):15-20. doi: 10.1111/j.1471-0528.2005.00805.x.

DOI:10.1111/j.1471-0528.2005.00805.x
PMID:16398765
Abstract

OBJECTIVES

To study changes in attitudes, knowledge and management strategies concerning hormone replacement therapy (HRT) among gynaecologists in Sweden.

DESIGN

Comparative questionnaire study.

SETTING

National survey.

POPULATION

Practising gynaecologists.

METHODS

In 1996, gynaecologists in Sweden (n= 1323) were invited to return a postal questionnaire concerning their attitudes, knowledge and management strategies concerning HRT. They were also asked about their own use of HRT. In 2003, a similar questionnaire was sent to practising gynaecologists (n= 1320) in Sweden.

MAIN OUTCOME MEASURES

Attitudes to and personal use of HRT.

RESULTS

The response rate was 76% in 2003 when 11% of the gynaecologists thought that all women without contraindications should be offered HRT compared with 44% in 1996 and 89% found it difficult to evaluate pros and cons with HRT in a clinical situation (74% in 1996). More gynaecologists in 2003 believed that HRT increased the risk for breast cancer (95% vs 71%). Twenty-five percent in 2003 stated that risk factors for osteoporosis were absolute indications for HRT (60% in 1996). Current ischaemic heart disease was considered to be an indication for HRT by 7% in 2003 (60% in 1996). In 2003, current use of HRT was reported by 71% of female menopausal gynaecologists (88% in 1996).

CONCLUSIONS

Swedish gynaecologists were more cautious in their management strategies concerning HRT in 2003 compared with 1996, probably influenced by results from the Heart and Estrogen/Progestin Replacement Study (HERS) and Women's Health Initiative (WHI) studies. Current use of HRT was still high among female gynaecologists, although it had decreased since 1996.

摘要

目的

研究瑞典妇科医生对激素替代疗法(HRT)的态度、知识和管理策略的变化。

设计

比较问卷调查研究。

背景

全国性调查。

研究对象

执业妇科医生。

方法

1996年,邀请瑞典的妇科医生(n = 1323)回复一份关于他们对HRT的态度、知识和管理策略的邮政问卷。还询问了他们自己使用HRT的情况。2003年,向瑞典的执业妇科医生(n = 1320)发送了类似的问卷。

主要观察指标

对HRT的态度和个人使用情况。

结果

2003年的回复率为76%,当时11%的妇科医生认为所有无禁忌证的女性都应接受HRT,而1996年为44%;89%的医生发现在临床情况下难以评估HRT的利弊(1996年为74%)。2003年更多的妇科医生认为HRT会增加患乳腺癌的风险(95%对71%)。2003年25%的医生表示骨质疏松症的危险因素是HRT的绝对适应证(1996年为60%)。2003年7%的医生认为目前的缺血性心脏病是HRT的适应证(1996年为60%)。2003年,71%的绝经女性妇科医生报告目前正在使用HRT(1996年为88%)。

结论

与1996年相比,2003年瑞典妇科医生在HRT管理策略上更加谨慎,这可能受到心脏与雌激素/孕激素替代研究(HERS)和妇女健康倡议(WHI)研究结果的影响。尽管自1996年以来HRT的使用有所下降,但女性妇科医生中目前的使用率仍然很高。

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