van Hierden Yvonne M, Koolhaas Jaap M, Kost'ál L'ubor, Výboh Pavel, Sedlacková Monika, Rajman Marek, Juráni Marian, Mechiel Korte S
Animal Sciences Group of Wageningen UR, Division of Animal Resources Development, Research group Animal Welfare, P.O. Box 65, NL-8200, AB Lelystad, The Netherlands.
Physiol Behav. 2005 Mar 16;84(3):471-7. doi: 10.1016/j.physbeh.2005.01.015.
Proactive rodents show a larger behavioral response to apomorphine (APO) than reactive copers, suggesting a more sensitive DA system in proactive individuals. Previously, chicks from a high feather pecking (HFP) and low feather pecking line (LFP) have been suggested to display a proactive and reactive coping strategy, respectively. Therefore, at approximately 4 weeks of age, the behavior of 48 LFP and 48 HFP chicks in response to an APO injection was studied using an open field. Another objective of the present study was to determine whether behavioral variation (in an open field) between HFP and LFP birds, after APO injection, is also reflected by variation of D(1) and D(2) receptor densities in the brain. Receptor binding capacities were assessed by measuring specific binding of tritiated D(1) and D(2) receptor ligands in different regions of the brain of control HFP and LFP chicks. In the present study, it is shown that indeed HFP chicks display a more enhanced behavioral response to acute APO treatment (0.5 mg/kg BW) than LFP birds in an open field. This difference was not reflected by variation of D(1) and D(2) receptor densities in the brain between both lines.
积极应对型啮齿动物对阿扑吗啡（APO）的行为反应比反应型应对者更大，这表明积极应对型个体的多巴胺（DA）系统更敏感。此前，有人提出来自高啄羽（HFP）品系和低啄羽品系（LFP）的雏鸡分别表现出积极应对和反应型应对策略。因此，在大约4周龄时，使用旷场实验研究了48只LFP雏鸡和48只HFP雏鸡对APO注射的行为反应。本研究的另一个目的是确定APO注射后，HFP和LFP雏鸡在旷场实验中的行为差异是否也反映在大脑中D(1)和D(2)受体密度的差异上。通过测量对照HFP和LFP雏鸡大脑不同区域中氚标记的D(1)和D(2)受体配体的特异性结合来评估受体结合能力。在本研究中，结果表明，在旷场实验中，HFP雏鸡对急性APO处理（0.5 mg/kg体重）的行为反应确实比LFP雏鸡更强烈。但两品系雏鸡大脑中D(1)和D(2)受体密度的差异并未反映出这种不同。
