加拿大的主动和被动吸烟与肾细胞癌风险

Active and passive smoking and risk of renal cell carcinoma in Canada.

作者信息

Hu Jinfu, Ugnat Anne-Marie

机构信息

Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, 120 Colonnade Road 6702A, AL: 6702A, Ottawa, Ontario, Canada K1A 0K9.

出版信息

Eur J Cancer. 2005 Mar;41(5):770-8. doi: 10.1016/j.ejca.2005.01.003.

DOI:10.1016/j.ejca.2005.01.003

PMID:15763654

Abstract

This study aimed to assess the role of active and passive smoking in the development of renal cell carcinoma (RCC). Mailed questionnaires were completed by 1279 incident RCC cases and 5370 population controls between 1994 and 1997 in eight Canadian provinces. Data were collected on socio-economic status, smoking habits, diet and passive smoking status, as well as residential and occupational history. The study found an increased risk of RCC associated with active smoking. Elevated risk of RCC was also observed with passive smoking; compared with those never exposed to either passive or active smoking, men and women with 43 or more years of passive residential and/or occupational exposure had respective adjusted Odds Ratios (ORs) of 3.9 (95% Confidence Interval (CI) 1.4-10.6) and 1.8 (95% CI 1.0-3.3) (P=0.001 and P=0.09, respectively). Both active and passive smoking might play a role in the aetiology of RCC.

摘要

本研究旨在评估主动吸烟和被动吸烟在肾细胞癌（RCC）发生发展中的作用。1994年至1997年间，在加拿大八个省份，1279例RCC新发病例和5370名人群对照完成了邮寄问卷调查。收集了社会经济状况、吸烟习惯、饮食和被动吸烟状况以及居住和职业史等数据。该研究发现主动吸烟与RCC风险增加有关。被动吸烟也观察到RCC风险升高；与从未接触过被动或主动吸烟的人相比，有43年或更长时间被动居住和/或职业接触史的男性和女性，其调整后的优势比（OR）分别为3.9（95%置信区间（CI）1.4 - 10.6）和1.8（95%CI 1.0 - 3.3）（P值分别为0.001和0.09）。主动吸烟和被动吸烟可能在RCC的病因学中都起作用。