Kalaitzis Christos, Touloupidis Stavros, Bantis Evangelos, Patris Emmanuel, Triantafyllidis Argyrios
Department of Urology, University of Thrace, 68100 Alexandroupolis, Greece.
Scand J Urol Nephrol. 2005;39(1):15-20. doi: 10.1080/00365590410018774.
To define the role of the renal nerves of the contralateral kidney in the maintenance of two-kidney, one-clip (2K-1C) renovascular hypertension in rats.
The contralateral kidney of 2K-1C rats was denervated 6 months after induction of hypertension and 4 weeks after nephrectomy of the clipped kidney. Blood pressure, sodium and potassium balance and eicosanoid excretion were measured.
Denervation of the contralateral kidney induced normalization of blood pressure in post-Goldblatt hypertensive rats. This effect was not mediated by a negative sodium balance. Excretion of prostaglandin E2 and thromboxane B2 increased after denervation of the contralateral kidney in both post-Goldblatt hypertensive and post-Goldblatt normotensive rats, while urine extraction remained unaffected.
Afferences from the contralateral kidney appear to participate in the maintenance of 2K-1C renovascular hypertension due to the activation of central mechanisms regulating blood pressure.
明确对侧肾脏肾神经在维持大鼠两肾一夹（2K-1C）肾血管性高血压中的作用。
在高血压诱导6个月后且夹闭肾切除4周后，对2K-1C大鼠的对侧肾脏进行去神经支配。测量血压、钠钾平衡和类花生酸排泄。
对侧肾脏去神经支配可使Goldblatt术后高血压大鼠的血压恢复正常。这种效应并非由负钠平衡介导。在Goldblatt术后高血压大鼠和Goldblatt术后血压正常的大鼠中，对侧肾脏去神经支配后前列腺素E2和血栓素B2的排泄均增加，而尿提取物不受影响。
由于调节血压的中枢机制被激活，对侧肾脏的传入神经似乎参与了2K-1C肾血管性高血压的维持。
