Dunn Nick, Holmes Clive, Mullee Mark
Primary Medical Care, University of Southampton, Southampton, UK.
Alzheimer Dis Assoc Disord. 2005 Jan-Mar;19(1):20-2. doi: 10.1097/01.wad.0000155068.23937.9b.
Lithium compounds might theoretically play a role in preventing dementia by inhibiting formation both of beta amyloid and hyper phosphorylated tau protein. We carried out a case-control study to assess any possible clinical effects of lithium therapy on the diagnosis of dementia, using data from the General Practice Research Database, which collects routine data from primary care patients in the UK. Patients who received lithium had a higher risk of a diagnosis of dementia compared with those who did not (adjusted odds ratio 1.8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia.
锂化合物理论上可能通过抑制β淀粉样蛋白和过度磷酸化tau蛋白的形成来预防痴呆。我们进行了一项病例对照研究，利用英国全科医学研究数据库的数据评估锂疗法对痴呆诊断的任何可能临床效果，该数据库收集来自英国基层医疗患者的常规数据。与未接受锂治疗的患者相比，接受锂治疗的患者被诊断为痴呆的风险更高（调整优势比为1.8，95%置信区间为1.1 - 2.8）。随着锂处方数量的增加，风险有上升趋势。该证据不支持使用锂来预防痴呆。
