心力衰竭中的线粒体能量代谢：平衡问题
Mitochondrial energy metabolism in heart failure: a question of balance.
作者信息
Huss Janice M, Kelly Daniel P
机构信息
Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
J Clin Invest. 2005 Mar;115(3):547-55. doi: 10.1172/JCI24405.
Abstract
The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.
摘要
线粒体作为能量转导、信号传导以及与心肌常见疾病（如心力衰竭）相关的细胞死亡途径的平台，发挥着关键作用。本综述聚焦于心力衰竭发展过程中已知会发生的线粒体能量代谢紊乱所涉及的分子调控事件和下游效应途径。
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