• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Death begets failure in the heart.死亡导致心脏功能衰竭。
J Clin Invest. 2005 Mar;115(3):565-71. doi: 10.1172/JCI24569.
2
[Regenerative and plastic heart failure: molecular biological mechanisms and morphological bases].
Arkh Patol. 2007 May-Jun;69(3):3-12.
3
[The role of cardiomyocyte apoptosis on mechanism of heart failure].[心肌细胞凋亡在心力衰竭机制中的作用]
Sheng Li Ke Xue Jin Zhan. 2000 Jul;31(3):265-8.
4
Altered intracellular Ca2+ handling in heart failure.心力衰竭时细胞内钙离子处理的改变。
J Clin Invest. 2005 Mar;115(3):556-64. doi: 10.1172/JCI24159.
5
A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.磷酸二酯酶3（PDE3）和诱导型环磷酸腺苷早期阻遏物（ICER）的正反馈回路会导致心肌细胞凋亡。
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14771-6. doi: 10.1073/pnas.0506489102. Epub 2005 Sep 26.
6
Cardiomyocyte apoptosis in the failing heart--a critical review from definition and classification of cell death.衰竭心脏中心肌细胞凋亡——从细胞死亡的定义和分类角度进行的重要综述
Int J Cardiol. 2013 Sep 10;167(6):2373-86. doi: 10.1016/j.ijcard.2013.01.163. Epub 2013 Feb 24.
7
Myocyte apoptosis in heart failure.心力衰竭中的心肌细胞凋亡
Cardiovasc Res. 2005 Jul 1;67(1):21-9. doi: 10.1016/j.cardiores.2005.04.012.
8
Effects of left ventricular volume overload on mitochondrial and death-receptor-mediated apoptotic pathways in the transition to heart failure.左心室容量超负荷在向心力衰竭转变过程中对线粒体和死亡受体介导的凋亡途径的影响。
Am J Cardiol. 2009 May 1;103(9):1261-8. doi: 10.1016/j.amjcard.2009.01.013.
9
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.心脏腺病毒介导的S100A1基因递送可挽救衰竭心肌。
J Clin Invest. 2004 Dec;114(11):1550-63. doi: 10.1172/JCI21454.
10
Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance.心力衰竭中的细胞重塑破坏了依赖于ATP敏感性钾通道的应激耐受性。
EMBO J. 2003 Apr 15;22(8):1732-42. doi: 10.1093/emboj/cdg192.

引用本文的文献

1
Fucoxanthin protects neonatal rat cardiomyocytes and attenuates high glucose-mediated oxidative stress via the AMPK pathway.岩藻黄质通过AMPK途径保护新生大鼠心肌细胞并减轻高糖介导的氧化应激。
Arch Med Sci. 2020 Apr 15;21(1):272-284. doi: 10.5114/aoms.2020.94432. eCollection 2025.
2
The Role of MicroRNAs in the Pathogenesis of Doxorubicin-Induced Vascular Remodeling.微小RNA在阿霉素诱导的血管重塑发病机制中的作用
Int J Mol Sci. 2024 Dec 12;25(24):13335. doi: 10.3390/ijms252413335.
3
Endothelial activation, cell-cell interactions, and inflammatory pathways in postoperative atrial fibrillation following cardiac surgery.心脏手术后房颤中的内皮激活、细胞间相互作用及炎症途径。
Biomed J. 2025 Aug;48(4):100821. doi: 10.1016/j.bj.2024.100821. Epub 2024 Nov 26.
4
Identification of novel biomarkers, shared molecular signatures and immune cell infiltration in heart and kidney failure by transcriptomics.通过转录组学鉴定心脏和肾脏衰竭中的新型生物标志物、共享分子特征和免疫细胞浸润。
Front Immunol. 2024 Sep 16;15:1456083. doi: 10.3389/fimmu.2024.1456083. eCollection 2024.
5
Elevated Troponins and Diagnosis of Non-ST-Elevation Myocardial Infarction in the Emergency Department.急诊科肌钙蛋白升高与非ST段抬高型心肌梗死的诊断
Cureus. 2024 May 8;16(5):e59910. doi: 10.7759/cureus.59910. eCollection 2024 May.
6
Roles of β-adrenoceptor Subtypes and Therapeutics in Human Cardiovascular Disease: Heart Failure, Tachyarrhythmias and Other Cardiovascular Disorders.β-肾上腺素受体亚型在人类心血管疾病中的作用及治疗：心力衰竭、心动过速性心律失常和其他心血管疾病。
Handb Exp Pharmacol. 2024;285:247-295. doi: 10.1007/164_2024_720.
7
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress.线粒体氧化应激促进压力超负荷小鼠右心衰竭
JACC Basic Transl Sci. 2022 Jul 6;7(7):658-677. doi: 10.1016/j.jacbts.2022.02.018. eCollection 2022 Jul.
8
A ROCK1 Inhibitior Fasudil Alleviates Cardiomyocyte Apoptosis in Diabetic Cardiomyopathy by Inhibiting Mitochondrial Fission in a Type 2 Diabetes Mouse Model.一种Rho相关卷曲螺旋蛋白激酶1（ROCK1）抑制剂法舒地尔通过抑制2型糖尿病小鼠模型中的线粒体分裂减轻糖尿病心肌病中的心肌细胞凋亡。
Front Pharmacol. 2022 Jul 5;13:892643. doi: 10.3389/fphar.2022.892643. eCollection 2022.
9
Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats.激活素受体样激酶 7 沉默减轻糖尿病大鼠心肌细胞凋亡、心脏纤维化和功能障碍。
Exp Biol Med (Maywood). 2022 Aug;247(16):1397-1409. doi: 10.1177/15353702221095049. Epub 2022 Jun 6.
10
Rhodiola rosea: A Therapeutic Candidate on Cardiovascular Diseases.红景天：一种心血管疾病的治疗候选药物。
Oxid Med Cell Longev. 2022 Feb 27;2022:1348795. doi: 10.1155/2022/1348795. eCollection 2022.

本文引用的文献

1
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.促凋亡蛋白BAX和BAK调节1型肌醇三磷酸受体以及内质网的钙泄漏。
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):105-10. doi: 10.1073/pnas.0408352102. Epub 2004 Dec 21.
2
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.胸腺素β4激活整合素连接激酶并促进心脏细胞迁移、存活及心脏修复。
Nature. 2004 Nov 25;432(7016):466-72. doi: 10.1038/nature03000.
3
The mitochondrial death pathway and cardiac myocyte apoptosis.线粒体死亡途径与心肌细胞凋亡
Circ Res. 2004 Nov 12;95(10):957-70. doi: 10.1161/01.RES.0000148632.35500.d9.
4
Autophagy in health and disease: a double-edged sword.健康与疾病中的自噬：一把双刃剑。
Science. 2004 Nov 5;306(5698):990-5. doi: 10.1126/science.1099993.
5
Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis.Bim转位至内质网介导内质网应激信号，在内质网应激诱导的细胞凋亡过程中激活半胱天冬酶-12。
J Biol Chem. 2004 Nov 26;279(48):50375-81. doi: 10.1074/jbc.M408493200. Epub 2004 Sep 27.
6
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.
Mol Cell. 2004 Sep 24;15(6):901-12. doi: 10.1016/j.molcel.2004.08.020.
7
The flip side of FLIP.FLIP的另一面。
Biochem J. 2004 Sep 1;382(Pt 2):e1-3. doi: 10.1042/BJ20041143.
8
Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis.主动脉缩窄后肥厚及衰竭心脏中的内质网应激延长：内质网应激对心肌细胞凋亡的可能作用
Circulation. 2004 Aug 10;110(6):705-12. doi: 10.1161/01.CIR.0000137836.95625.D4. Epub 2004 Aug 2.
9
Alkylating DNA damage stimulates a regulated form of necrotic cell death.烷基化DNA损伤会刺激一种受调控形式的坏死性细胞死亡。
Genes Dev. 2004 Jun 1;18(11):1272-82. doi: 10.1101/gad.1199904. Epub 2004 May 14.
10
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.人半胱天冬酶-12基因多态性对内毒素反应性的差异调节
Nature. 2004 May 6;429(6987):75-9. doi: 10.1038/nature02451.

死亡导致心脏功能衰竭。

Death begets failure in the heart.

作者信息

Foo Roger S-Y, Mani Kartik, Kitsis Richard N

机构信息

Department of Medicine, Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

出版信息

J Clin Invest. 2005 Mar;115(3):565-71. doi: 10.1172/JCI24569.

DOI:10.1172/JCI24569
PMID:15765138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1052022/
Abstract

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

摘要

最近，在衰竭的人类心脏中观察到心肌细胞凋亡率较低但异常。遗传学和药理学研究表明，在啮齿动物模型中，这种细胞死亡与心力衰竭存在因果关系。在此，我们回顾这些数据并讨论潜在的治疗意义。