阐明I型干扰素在结肠炎中的作用。
Illuminating the role of type I IFNs in colitis.
作者信息
Wirtz Stefan, Neurath Markus F
机构信息
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Mainz, Germany.
出版信息
J Clin Invest. 2005 Mar;115(3):586-8. doi: 10.1172/JCI24518.
Abstract
Recently, type I interferons IFN-alpha and IFN-beta (IFN-alpha/beta) have been evaluated in pilot clinical trials for the treatment of active ulcerative colitis. However, the underlying mechanisms that may contribute to a potential therapeutic effect are incompletely understood. A new study in this issue demonstrates a protective role for IFN-alpha/beta, induced by activation of a Toll-like receptor 9-dependent pathway, in a rodent model of experimental colitis.
摘要
最近，I型干扰素α和β（IFN-α/β）已在治疗活动性溃疡性结肠炎的初步临床试验中进行了评估。然而，可能促成潜在治疗效果的潜在机制尚未完全了解。本期的一项新研究表明，在实验性结肠炎的啮齿动物模型中，由Toll样受体9依赖性途径激活诱导的IFN-α/β具有保护作用。
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