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The metabolic actions of thyroid hormone and leptin: a mandatory interplay or not?

作者信息

Vettor R

机构信息

Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padua, University Hospital, via Ospedale 105, 35128 Padua, Italy.

出版信息

Diabetologia. 2005 Apr;48(4):621-3. doi: 10.1007/s00125-005-1703-9. Epub 2005 Mar 12.

DOI:10.1007/s00125-005-1703-9
PMID:15765220
Abstract
摘要

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本文引用的文献

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Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion.大鼠甲状腺功能减退会降低外周葡萄糖利用率，而通过中枢注射瘦素可部分纠正这一缺陷。
Diabetologia. 2005 Apr;48(4):624-33. doi: 10.1007/s00125-005-1696-4. Epub 2005 Mar 9.
2
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.AMP激酶激活剂AICAR对瘦素抵抗大鼠的拟瘦素样作用：预防糖尿病和异位脂质沉积
Diabetologia. 2004 Nov;47(11):2012-21. doi: 10.1007/s00125-004-1570-9. Epub 2004 Dec 2.
3
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
母乳中瘦素浓度及其与哺乳期时长和激素状态的关系。
Int Breastfeed J. 2006 Nov 17;1:21. doi: 10.1186/1746-4358-1-21.
瘦素通过激活AMP活化蛋白激酶来刺激脂肪酸氧化。
Nature. 2002 Jan 17;415(6869):339-43. doi: 10.1038/415339a.
4
Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin.瘦素在内分泌、自主神经和行为效应方面的下丘脑通路。
Physiol Behav. 2001 Nov-Dec;74(4-5):703-8. doi: 10.1016/s0031-9384(01)00613-8.
5
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.AMP激酶的激活增强了肌肉葡萄糖转运对胰岛素的敏感性。
Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E18-23. doi: 10.1152/ajpendo.2002.282.1.E18.
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5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside.在小鼠C2C12肌管中，5'-腺苷酸激活蛋白激酶响应5-氨基咪唑-4-甲酰胺核苷使胰岛素受体底物-1（IRS-1）的丝氨酸789位点发生磷酸化。
J Biol Chem. 2001 Dec 14;276(50):46912-6. doi: 10.1074/jbc.C100483200. Epub 2001 Oct 11.
7
Physiological and molecular basis of thyroid hormone action.甲状腺激素作用的生理和分子基础。
Physiol Rev. 2001 Jul;81(3):1097-142. doi: 10.1152/physrev.2001.81.3.1097.
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Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling.瘦素和黑皮质素信号对促甲状腺激素释放激素基因的转录调控。
J Clin Invest. 2001 Jan;107(1):111-20. doi: 10.1172/JCI10741.
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