Suppr超能文献

[骨髓细胞移植治疗慢性恰加斯病性心肌病]

[Bone marrow cells transplant in the treatment of chronic chagasic cardiomyopathy].

作者信息

dos Santos Ricardo Ribeiro, Soares Milena Botelho Pereira, de Carvalho Antônio Carlos Campos

机构信息

Centro de Pesquisas Gonçalo Moniz da Fundaçao Oswaldo Cruz, Salvador, BA, Brasil.

出版信息

Rev Soc Bras Med Trop. 2004 Nov-Dec;37(6):490-5. doi: 10.1590/s0037-86822004000600012.

Abstract

Chronic chagasic cardiomyopathy remains a major cause of death due to heart failure in Latin American countries and for which there is currently no effective treatment. While chagasic patients wait for the development of more efficient and less toxic chemotherapeutics for the elimination of Trypanosoma cruzi, a new strategy has appeared in an attempt to repair or ameliorate the damage caused to the myocardium of patients with chronic chagasic cardiomyopathy. This therapy, involving the transplant of bone marrow cells obtained from the patient to be treated, may lead to improvement in heart function and in life quality of patients with severe chagasic cardiopathy, similar to that obtained with this approach in the treatment of patients with heart failure of ischemic etiology. The possible effects of cell therapies and its applications in chronic chagasic cardiopaths are discussed in the present report.

摘要

在拉丁美洲国家,慢性恰加斯病性心肌病仍然是导致心力衰竭死亡的主要原因,目前尚无有效治疗方法。在恰加斯病患者等待开发出更高效、毒性更小的化疗药物以消灭克氏锥虫的过程中,一种新策略应运而生,旨在修复或改善慢性恰加斯病性心肌病患者心肌所受的损伤。这种疗法是将从待治疗患者身上获取的骨髓细胞进行移植,可能会改善重症恰加斯病性心肌病患者的心脏功能和生活质量,类似于这种方法在治疗缺血性病因心力衰竭患者时所取得的效果。本报告讨论了细胞疗法的可能效果及其在慢性恰加斯病患者中的应用。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验