dos Santos Ricardo Ribeiro, Soares Milena Botelho Pereira, de Carvalho Antônio Carlos Campos
Centro de Pesquisas Gonçalo Moniz da Fundaçao Oswaldo Cruz, Salvador, BA, Brasil.
Rev Soc Bras Med Trop. 2004 Nov-Dec;37(6):490-5. doi: 10.1590/s0037-86822004000600012.
Chronic chagasic cardiomyopathy remains a major cause of death due to heart failure in Latin American countries and for which there is currently no effective treatment. While chagasic patients wait for the development of more efficient and less toxic chemotherapeutics for the elimination of Trypanosoma cruzi, a new strategy has appeared in an attempt to repair or ameliorate the damage caused to the myocardium of patients with chronic chagasic cardiomyopathy. This therapy, involving the transplant of bone marrow cells obtained from the patient to be treated, may lead to improvement in heart function and in life quality of patients with severe chagasic cardiopathy, similar to that obtained with this approach in the treatment of patients with heart failure of ischemic etiology. The possible effects of cell therapies and its applications in chronic chagasic cardiopaths are discussed in the present report.
在拉丁美洲国家,慢性恰加斯病性心肌病仍然是导致心力衰竭死亡的主要原因,目前尚无有效治疗方法。在恰加斯病患者等待开发出更高效、毒性更小的化疗药物以消灭克氏锥虫的过程中,一种新策略应运而生,旨在修复或改善慢性恰加斯病性心肌病患者心肌所受的损伤。这种疗法是将从待治疗患者身上获取的骨髓细胞进行移植,可能会改善重症恰加斯病性心肌病患者的心脏功能和生活质量,类似于这种方法在治疗缺血性病因心力衰竭患者时所取得的效果。本报告讨论了细胞疗法的可能效果及其在慢性恰加斯病患者中的应用。