骨髓细胞疗法可改善并逆转小鼠模型中的恰加斯病性心肌病。
Bone marrow cell therapy ameliorates and reverses chagasic cardiomyopathy in a mouse model.
作者信息
Goldenberg Regina C S, Jelicks Linda A, Fortes Fabio S A, Weiss Louis M, Rocha Leonardo L, Zhao Dazhi, Carvalho Antonio Campos de, Spray David C, Tanowitz Herbert B
机构信息
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
J Infect Dis. 2008 Feb 15;197(4):544-7. doi: 10.1086/526793.
Abstract
Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. It is a disease for which effective treatment in its advanced clinical forms is lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation is effective in reducing inflammation and fibrosis in the mouse model of Chagas disease. The present study used magnetic resonance imaging to assess changes in the cardiac morphology of infected mice after therapy with BMCs. Serial imaging of the BMC-treated mice revealed regression of the right ventricular dilatation typically observed in the chagasic mouse model.
摘要
慢性恰加斯病性心肌病由原生动物克氏锥虫引起，是拉丁美洲心力衰竭的主要病因。这是一种晚期临床症状缺乏有效治疗方法的疾病。我们之前已经表明，骨髓单个核细胞（BMC）移植在恰加斯病小鼠模型中可有效减轻炎症和纤维化。本研究使用磁共振成像评估了BMC治疗后感染小鼠心脏形态的变化。对接受BMC治疗的小鼠进行的连续成像显示，恰加斯病小鼠模型中典型的右心室扩张现象出现了消退。
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