White Jason F, Levin Linda, Villareal Manuel, Murphy Karen, Biagini Raymond, Wellinghoff Lisa, St Clair Harry G, Bernstein David I
Division of Immunology-Allergy, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0563, USA.
Ann Allergy Asthma Immunol. 2005 Feb;94(2):240-6. doi: 10.1016/s1081-1206(10)61302-6.
Although seasonal patterns of tree pollination have been reported, it is unknown if aerobiologic data correlate with patterns of in vivo sensitization.
To evaluate the relationship between regional tree pollen exposure and patterns of in vivo percutaneous reactivity to specific tree pollen extracts in a local patient population with seasonal allergic rhinitis.
Patients with spring seasonal allergic rhinitis and percutaneous sensitivity to 1 or more regional tree pollens were studied. Tree pollen counts were collected at the same urban site from 1997 to 2002 and at a suburban site in 2002. Patients underwent skin prick testing with commercial extracts of 15 indigenous tree species. Serum specific IgE measurements were assayed in a subset of sensitized patients.
Of 127 patients who reported symptoms consistent with seasonal allergic rhinitis during the spring pollen season, 93 qualified based on demonstration of at least 1 positive skin prick test result. Mean 5-year pollen counts (1997-2001) and 2002 urban counts were highly correlated (Spearman r = 0.95, P < .001), indicating that year-to-year pollen counts were consistent. No significant correlation was found between mean seasonal pollen counts (urban site, 1997-2001) and frequencies of skin prick test reactivity to specific tree pollen allergens (Spearman r = -0.03, P = .93). No significant relationship was found between 5-year mean tree pollen counts and positive serum specific IgE tests for specific tree pollens (Spearman r = -0.42, P = .30). Eight of 15 species elicited percutaneous reactions in more than 50% of patients (ie, satisfying definition of a major in vivo allergen). However, 6 of the 8 major tree allergens each represented 5% or less of 5-year mean total tree pollen counts.
No correlation was found between overall frequencies of in vivo sensitization to tree pollen allergens in a local population and regional pollen exposure data.
尽管已有关于树木授粉季节模式的报道，但尚不清楚空气生物学数据是否与体内致敏模式相关。
评估局部季节性变应性鼻炎患者群体中，区域树木花粉暴露与对特定树木花粉提取物的体内皮肤反应模式之间的关系。
对患有春季季节性变应性鼻炎且对1种或更多区域树木花粉具有皮肤敏感性的患者进行研究。1997年至2002年在同一城市地点以及2002年在一个郊区地点收集树木花粉计数。患者接受了15种本地树种商业提取物的皮肤点刺试验。对一部分致敏患者进行血清特异性IgE检测。
在127名报告在春季花粉季节出现与季节性变应性鼻炎相符症状的患者中，93名基于至少1次阳性皮肤点刺试验结果符合条件。5年平均花粉计数（1997 - 2001年）与2002年城市计数高度相关（Spearman秩相关系数r = 0.95，P <.001），表明逐年花粉计数是一致的。未发现平均季节性花粉计数（城市地点，1997 - 2001年）与对特定树木花粉过敏原的皮肤点刺试验反应频率之间存在显著相关性（Spearman秩相关系数r = -0.03，P =.93）。未发现5年平均树木花粉计数与特定树木花粉的血清特异性IgE阳性检测之间存在显著关系（Spearman秩相关系数r = -0.42，P =.30）。15种树种中有8种在超过50%的患者中引起皮肤反应（即符合主要体内过敏原的定义）。然而，这8种主要树木过敏原中有6种每种在5年平均树木花粉总数中所占比例为5%或更低。
在局部人群中，对树木花粉过敏原的体内致敏总体频率与区域花粉暴露数据之间未发现相关性。
