Morańska Izabella, Jurczyk Krzysztof, Kłosińska Ewa, Wiśniewski Krzysztof, Karpińska Ewa, Wawrzynowicz-Syczewska Marta, Urbanowicz Waldemar, Rzechuła Henryk, Boroń-Kaczmarska Anna
Katedry i Kliniki Chorób Zakaźnych, Pomorskiej Akademii Medycznej, Szczecinie.
Wiad Lek. 2004;57(9-10):427-30.
The activity of alanine aminotransferase (ALT) is the most popular parameter in hepatology. Increase of ALT usually suggests the damage of hepatocytes. The aim of the study was to assess the range of value of serum alanine aminotransferase in healthy population and to assess the relationship between ALT level and body mass index (BMI), age and gender. We have analyzed a large population of healthy blood donors--all of them were screened for ALT, weight and height. Patients were divided into four groups: I--patients with underweight, II--patients with normal weight, III--patients with overweight, IV--obese patients. In the studied population 862 persons were taken into account (820 men and 42 women), 19-62 years of age. The ALT level varied from 6 to 77 U/L, mean 27.39 U/L. Inadequate BMI was found in 12 persons, normal BMI in 497 persons, overweight in 270 persons and obesity in 83 persons. ALT and BMI are statistically significantly higher in men than in women. In general population and in men group we found correlations between ALT and BMI (p = 0.0000), between ALT and age (p = 0.0000). In women we did not find those dependences. ALT level was statistically significantly higher in groups with higher BMI: ALT level in group II was higher than in group I (p < 0.024), ALT level in group III was higher than in group III (p = 0.0000). We did not find any differences in ALT level between group III and IV. ALT level strongly correlates with body mass, age and gender. We suggest the necessity of taking into consideration those parameters in a clinical interpretation of ALT level.
丙氨酸氨基转移酶（ALT）活性是肝病学中最常用的参数。ALT升高通常提示肝细胞损伤。本研究旨在评估健康人群血清丙氨酸氨基转移酶的数值范围，并评估ALT水平与体重指数（BMI）、年龄和性别的关系。我们分析了大量健康献血者——所有人都进行了ALT、体重和身高筛查。患者被分为四组：I组——体重过轻患者，II组——体重正常患者，III组——超重患者，IV组——肥胖患者。在研究人群中纳入了862人（820名男性和42名女性），年龄在19至62岁之间。ALT水平在6至77 U/L之间，平均为27.39 U/L。发现12人体重指数不达标，497人体重指数正常，270人超重，83人肥胖。男性的ALT和BMI在统计学上显著高于女性。在总体人群和男性组中，我们发现ALT与BMI之间（p = 0.0000）、ALT与年龄之间（p = 0.0000）存在相关性。在女性中未发现这些相关性。BMI较高组的ALT水平在统计学上显著更高：II组的ALT水平高于I组（p < 0.024），III组的ALT水平高于II组（p = 0.0000）。我们未发现III组和IV组之间的ALT水平有任何差异。ALT水平与体重、年龄和性别密切相关。我们建议在临床解释ALT水平时必须考虑这些参数。
