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[儿童尿路感染——病原体及对抗生素的敏感性]

[Urinary tract infections in children--etiologic agents and susceptibility to antibiotics].

作者信息

Nowakowska Maria, Rogala-Zawada Danuta, Wiechuła Barbara, Rudy Maria, Radosz-Komoniewska Halina, Zientara Maria

机构信息

Katedry i Zakładu Mikrobiologii Lekarskiej, Slaskiej Akademii Medycznej w Katowicach.

出版信息

Wiad Lek. 2004;57(9-10):438-43.

Abstract

Urinary tract infections (UTIs) are common clinical problem in pediatric hospitals. The aim of this study was to compare the incidence of UTIs during two different time periods (from February 1999 to March 2000, and from April 2000 to September 2001) in pediatric patients treated in ambulatory or hospitalized in new children hospital. The frequency of occurrence of ESBL--producing Gram-negative rods increased during second period study. The isolated ESBL--producing strains were resistant also to aminoglicosides and trimethoprim/sulfamethoxazol Gram-negative rods were predominant microorganisms. Isolated organisms from urine samples included Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Proteus mirabilis, Proteus penneri, Proteus vulgaris, Morganella morganii, Citrobacter freundi, Serratia spp., Enterobacter cloacae, Pseudomonas aeruginosa, Staphylococcus aureus, CNS, Enterococcus spp. Streptococcus spp, and Candida spp. Enterococcus spp. were isolated from urine samples in 20% of cases. Only 9.4% of isolated Enterococcus spp. were high-level aminoglicoside resistant (HLAR) strains. No vancomycin-resistant Enterococcus spp. were isolated. Among coagulase-negative Staphylococci (CNS) methicillin resistant strains (MRCNS) were isolated in 43.3%.

摘要

尿路感染(UTIs)是儿科医院常见的临床问题。本研究的目的是比较在新儿童医院接受门诊治疗或住院治疗的儿科患者在两个不同时间段(1999年2月至2000年3月,以及2000年4月至2001年9月)期间尿路感染的发生率。在第二个研究期间,产超广谱β-内酰胺酶(ESBL)的革兰氏阴性杆菌的出现频率增加。分离出的产ESBL菌株对氨基糖苷类和甲氧苄啶/磺胺甲恶唑也具有抗性,革兰氏阴性杆菌是主要的微生物。从尿液样本中分离出的微生物包括大肠杆菌、肺炎克雷伯菌、产酸克雷伯菌、奇异变形杆菌、彭氏变形杆菌、普通变形杆菌、摩根摩根菌、弗氏柠檬酸杆菌、沙雷菌属、阴沟肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、凝固酶阴性葡萄球菌(CNS)、肠球菌属、链球菌属和念珠菌属。20%的病例从尿液样本中分离出肠球菌属。分离出的肠球菌属中只有9.4%是高水平氨基糖苷类耐药(HLAR)菌株。未分离出耐万古霉素的肠球菌属。在凝固酶阴性葡萄球菌(CNS)中,43.3%分离出耐甲氧西林菌株(MRCNS)。

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