eder-Ischia Ursula, Ebenbichler Christoph, Fleischhacker W Wolfgang
Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria.
Essent Psychopharmacol. 2005;6(2):112-7.
Among the atypical antipsychotics, clozapine and olanzapine are known to cause significant weight gain. Along with quetiapine, they may impair glucose metabolism and increase the risk for type 2 diabetes. They are also associated with a rise in triglyceride levels and an increased risk for coronary artery disease. Clinicians should take these risks seriously in prescribing these antipsychotics and employ intelligent safeguards if and when they use them.
在非典型抗精神病药物中，已知氯氮平和奥氮平会导致显著体重增加。与喹硫平一起，它们可能损害葡萄糖代谢并增加2型糖尿病风险。它们还与甘油三酯水平升高及冠状动脉疾病风险增加有关。临床医生在开具这些抗精神病药物处方时应认真对待这些风险，并且在使用时应采取明智的预防措施。
