Resnick Michael A
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
Cell. 2005 Mar 11;120(5):569-70. doi: 10.1016/j.cell.2005.02.028.
In this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication.
在本期《细胞》杂志中，勒莫因等人监测了必需复制性DNA聚合酶水平降低的酵母细胞中的染色体不稳定性。作者们发现了一个染色体畸变热点，让人联想到人类细胞中的脆性位点。这个热点由反向Ty元件组成，在复制受限的条件下会导致双链断裂。
