DNA 复制保真度与癌症。
DNA replication fidelity and cancer.
机构信息
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
出版信息
Semin Cancer Biol. 2010 Oct;20(5):281-93. doi: 10.1016/j.semcancer.2010.10.009. Epub 2010 Oct 15.
Abstract
Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.
摘要
癌症由突变驱动，并受到适应性选择的影响。正常细胞通过极其精确地复制基因组来避免有害突变。在这里，我们回顾了控制 DNA 复制保真度的途径，并讨论了复制错误（点突变不稳定性或 PIN）在致癌作用中的证据。
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