新的细菌细胞生物学：活动部件与亚细胞结构

The new bacterial cell biology: moving parts and subcellular architecture.

作者信息

Gitai Zemer

机构信息

Department of Developmental Biology, Beckman Center, School of Medicine, Stanford University, Stanford, CA 94305, USA.

出版信息

Cell. 2005 Mar 11;120(5):577-86. doi: 10.1016/j.cell.2005.02.026.

DOI:10.1016/j.cell.2005.02.026

PMID:15766522

Abstract

Recent advances have demonstrated that bacterial cells have an exquisitely organized and dynamic subcellular architecture. Like their eukaryotic counterparts, bacteria employ a full complement of cytoskeletal proteins, localize proteins and DNA to specific subcellular addresses at specific times, and use intercellular signaling to coordinate multicellular events. The striking conceptual and molecular similarities between prokaryotic and eukaryotic cell biology thus make bacteria powerful model systems for studying fundamental cellular questions.

摘要

最近的进展表明，细菌细胞具有高度组织化且动态的亚细胞结构。与真核细胞类似，细菌运用全套细胞骨架蛋白，在特定时间将蛋白质和DNA定位到特定的亚细胞位置，并利用细胞间信号传导来协调多细胞事件。因此，原核细胞生物学与真核细胞生物学之间显著的概念和分子相似性，使细菌成为研究基本细胞问题的强大模型系统。