Pei Duanqing
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Cancer Cell. 2005 Mar;7(3):207-8. doi: 10.1016/j.ccr.2005.02.011.
Matrix metalloproteinases, or MMPs, have been implicated in tumor invasion and metastasis by virtue of their ability to degrade the extracellular matrix (ECM) barrier. However, MMPs are also capable of cleaving non-ECM molecules. The protease-activated receptors (PARs) are the latest MMP targets. The thrombin receptor PAR1 has now been shown to be cleaved and activated on the tumor cell surface by stromal-derived MMP1. The resulting PAR1 activates intracellular G proteins to turn on the migratory and invasive program in tumor cells. This MMP-PAR axis may represent a novel signaling pathway communicating between tumor and stromal cells during tumor progression.
基质金属蛋白酶（MMPs）因其能够降解细胞外基质（ECM）屏障而与肿瘤侵袭和转移有关。然而，MMPs也能够切割非ECM分子。蛋白酶激活受体（PARs）是MMPs的最新作用靶点。现已证明，基质来源的MMP1可在肿瘤细胞表面切割并激活凝血酶受体PAR1。产生的PAR1激活细胞内G蛋白，从而开启肿瘤细胞的迁移和侵袭程序。在肿瘤进展过程中，这种MMP-PAR轴可能代表了一种肿瘤细胞与基质细胞之间进行通讯的新型信号通路。
