Shuster Linda I, Lemieux Susan K
Department of Speech Pathology and Audiology, Center for Advanced Imaging, West Virginia University, Morgantown, WV 26506-9236, USA.
Brain Lang. 2005 Apr;93(1):20-31. doi: 10.1016/j.bandl.2004.07.007.
Studies suggest that the left insula may play an important role in speech motor programming. We used functional magnetic resonance imaging to investigate the role of the left insula in the production of monosyllabic or multisyllabic words during overt and covert speech conditions. The left insula did not show a BOLD response for multisyllabic words (which should require more speech motor programming) that was different from that for monosyllabic words. Left parietal lobe regions showed a greater response for multisyllabic as compared to monosyllabic words. This is consistent with clinical studies showing that left parietal lobe lesions can produce a deficit in speech programming. Despite similarities, covert and overt speech did not demonstrate the same patterns of BOLD response. The BOLD response was greater during overt speech in areas that have been shown to play an important role in speech production including left premotor cortex/BA6, left primary motor cortex, left insula, and left superior temporal gyrus.
研究表明，左侧脑岛可能在言语运动编程中发挥重要作用。我们使用功能磁共振成像来研究左侧脑岛在公开和隐蔽言语条件下产生单音节或多音节单词时的作用。左侧脑岛对多音节单词（应该需要更多的言语运动编程）未表现出与单音节单词不同的血氧水平依赖（BOLD）反应。与单音节单词相比，左侧顶叶区域对多音节单词表现出更大的反应。这与临床研究一致，临床研究表明左侧顶叶病变可导致言语编程缺陷。尽管存在相似之处，但隐蔽和公开言语并未表现出相同的BOLD反应模式。在已被证明在言语产生中起重要作用的区域，包括左侧运动前皮层/BA6、左侧初级运动皮层、左侧脑岛和左侧颞上回，公开言语期间的BOLD反应更大。
