Nishioka Y, Kyotani S, Okamura M, Miyazaki M, Sakamoto Y, Morita M, Okazaki K, Ohnishi S, Yamamoto Y, Ito K
Department of Pharmacy, Kochi Medical School Hospital, Japan.
Chem Pharm Bull (Tokyo). 1992 Jan;40(1):267-8. doi: 10.1248/cpb.40.267.
Hepatic artery of dogs was embolized with cisplatin (CDDP) albumin microspheres containing chitin and chitosan to investigate the in vivo CDDP release kinetics from CDDP albumin microspheres, the CDDP cumulative characteristics in the liver, and the influence of microsphere administration on hepatic tissue. Results showed that changes in blood CDDP content were dependent on CDDP albumin microsphere type and that release kinetics were better sustained when chitin was added to the microspheres or when the microspheres were treated with chitosan. In particular, the administration of CDDP in the chitin-containing CDDP chitosan albumin microspheres showed a blood CDDP content of approximately 0.26 micrograms Pt/ml 14 d after administration. The administration of chitin-containing or chitosan treated CDDP microspheres showed a CDDP content in the hepatic tissue of 0.14 to 0.23 micrograms Pt/g 28 d after administration. They also showed better control of CDDP release than those without chitin or chitosan treatment. No CDDP influence on hepatic tissue was observed. We conclude that, even in vivo, chitin and chitosan are effective embolic materials.
用含甲壳素和壳聚糖的顺铂（CDDP）白蛋白微球栓塞犬肝动脉，以研究CDDP白蛋白微球在体内的CDDP释放动力学、CDDP在肝脏中的累积特性以及微球给药对肝组织的影响。结果表明，血液中CDDP含量的变化取决于CDDP白蛋白微球的类型，当向微球中添加甲壳素或用壳聚糖处理微球时，释放动力学能得到更好的维持。特别是，含甲壳素的CDDP壳聚糖白蛋白微球给药后14天，血液中CDDP含量约为0.26微克铂/毫升。含甲壳素或经壳聚糖处理的CDDP微球给药后28天，肝组织中CDDP含量为0.14至0.23微克铂/克。与未用甲壳素或壳聚糖处理的微球相比，它们对CDDP释放的控制也更好。未观察到CDDP对肝组织有影响。我们得出结论，即使在体内，甲壳素和壳聚糖也是有效的栓塞材料。
