Wang Y M, Shi T S, Pu Y L, Zhu J G, Zhao Y L
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
Yao Xue Xue Bao. 1996;31(4):300-5.
In this paper, the preparation, drug content, size and size distribution, appearance and morphology, release characteristics in vitro and degradation characteristics of cisplatin chitosan microspheres (CDDP-DAC-MS) were studied. CDDP-DAC-MS were prepared by emulsion-crosslink technique. The CDDP-DAC-MS was shown to have rough spherical surface under scanning electron microscopy. The average diameter of the microspheres was 74.80 microns and CDDP content was 20.83% +/- 0.36%. CDDP-DAC-MS swelled slightly in saline after 1 h. Within the test period, the release of CDDP from CDDP-DAC-MS in saline solution could be described by first-order equation. The microspheres were sterilized by 60Co radiation. After 28 d of hepatic artery embolization with CDDP-DAC-MS in dogs, pathological photomicrograph showed that CDDP-DAC-MS could still be observed.
本文研究了顺铂壳聚糖微球（CDDP-DAC-MS）的制备、药物含量、粒径及粒径分布、外观与形态、体外释放特性和降解特性。采用乳化交联技术制备CDDP-DAC-MS。扫描电子显微镜下显示CDDP-DAC-MS表面粗糙呈球形。微球的平均直径为74.80微米，顺铂含量为20.83%±0.36%。CDDP-DAC-MS在盐水中1小时后略有膨胀。在测试期间，CDDP-DAC-MS在盐溶液中的释放可用一级方程描述。微球经60Co辐射灭菌。用CDDP-DAC-MS对犬进行肝动脉栓塞28天后，病理显微照片显示仍可观察到CDDP-DAC-MS。
