恩诺沙星对大美洲鸵静脉注射后的药代动力学：一项初步研究。
Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study.
作者信息
de Lucas J J, Rodríguez C, Martella M B, Lábaque M C, Navarro J L, San Andrés M I
机构信息
Departmento de Toxicología y Farmacología, Cátedra de Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/ Puerta de Hierro s.n., 28040 Madrid, Spain.
出版信息
Res Vet Sci. 2005 Jun;78(3):265-7. doi: 10.1016/j.rvsc.2004.09.007. Epub 2004 Dec 15.
The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (V(ss)=5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t(1/2beta)=2.66 h and MRT=1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR+CIP).
在六只大美洲鸵单次静脉注射15毫克/千克体重的恩诺沙星（ENR）后，测定了其药代动力学行为及其活性代谢物环丙沙星（CIP）。采用高效液相色谱/紫外法同时测定血浆中ENR和CIP的浓度。静脉注射给药后，血浆药物浓度最适合用具有快速分布相的开放二室模型来拟合。高分布容积（V（ss）=5.01升/千克）表明组织穿透力良好。ENR具有高清除率（3.95升/千克·小时），这解释了其低药时曲线下面积值（3.57毫克·小时/升）和短滞留时间（t（1/2β）=2.66小时，平均滞留时间=1.23小时）。环丙沙星占总氟喹诺酮（ENR+CIP）的14%。
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