CD62L和CCR7共表达揭示的复杂记忆性T细胞表型
Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7.
作者信息
Unsoeld Heike, Pircher Hanspeter
机构信息
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.
出版信息
J Virol. 2005 Apr;79(7):4510-3. doi: 10.1128/JVI.79.7.4510-4513.2005.
Abstract
Antigen-experienced T cells have been divided into CD62L+ CCR7+ central memory (TCM) and CD62L- CCR7- effector memory (TEM) cells. Here, we examined coexpression of CD62L and CCR7 in lymphocytic choriomeningitis virus-specific memory CD8 T cells from both lymphoid and nonlymphoid tissues. Three main points emerged: firstly, memory cells frequently expressed a mixed CD62L- CCR7+ phenotype that differed from the phenotypes of classical TEM and TCM cells; secondly, TCM cells were not restricted to lymphoid organs but were also present in significant numbers in nonlymphoid tissues; and thirdly, a major shift from a TCM to TEM phenotype was found in memory cells that had been stimulated repetitively with antigen.
摘要
抗原接触过的T细胞已被分为CD62L+ CCR7+ 中央记忆（TCM）细胞和CD62L- CCR7- 效应记忆（TEM）细胞。在此，我们检测了来自淋巴组织和非淋巴组织的淋巴细胞性脉络丛脑膜炎病毒特异性记忆CD8 T细胞中CD62L和CCR7的共表达情况。出现了三个主要要点：第一，记忆细胞经常表达一种混合的CD62L- CCR7+ 表型，该表型不同于经典TEM细胞和TCM细胞的表型；第二，TCM细胞并不局限于淋巴器官，在非淋巴组织中也大量存在；第三，在被抗原反复刺激的记忆细胞中发现了从TCM表型到TEM表型的主要转变。
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