Pflum L R, Graeme M L
Agents Actions. 1979 Jun;9(2):184-9. doi: 10.1007/BF02024732.
The Arthus reaction is an immunologically induced inflammatory response characterized by immune complex deposition, complement fixation, polymorphonuclear leukocyte infiltration and tissue damage. Many of these same pathological tissue alterations are found in the lesions of rheumatoid arthritis (RA). The similarities between the reversed passive Arthus reaction (RPAR) and RA led us to investigate the usefulness of the RPAR in the search for new antirheumatic agents. The RPAR was elicited in the skin of rats using chicken ovalbumin and the IgG fraction of rabbit anti-ovalbumin. Paramethasone, hydrocortisone, indomethacin, pirprofen, sulfinpyrazone, thalidomide and theophylline all gave significant inhibition of the RPAR. Ibuprofen, naproxen, cyprohepatadine and cromolyn sodium were inactive, while phenylbutazone and ASA exhibited a dose-dependent effect. The data show that the Arthus reaction, which is the result of the complex interaction of many factors, can be affected either generally or selectively at different time intervals by various therapeutic agents. The RPAR in rats may prove useful in detecting new therapeutic agents for the treatment of RA.
阿瑟氏反应是一种免疫诱导的炎症反应，其特征为免疫复合物沉积、补体固定、多形核白细胞浸润及组织损伤。类风湿性关节炎（RA）的病变中也存在许多相同的病理组织改变。反向被动阿瑟氏反应（RPAR）与RA之间的相似性促使我们研究RPAR在寻找新型抗风湿药物方面的实用性。使用鸡卵清蛋白和兔抗卵清蛋白IgG组分在大鼠皮肤中引发RPAR。对氟米松、氢化可的松、吲哚美辛、吡洛芬、磺吡酮、沙利度胺和茶碱均对RPAR有显著抑制作用。布洛芬、萘普生、赛庚啶和色甘酸钠无活性，而保泰松和阿司匹林呈现剂量依赖性效应。数据表明，阿瑟氏反应作为多种因素复杂相互作用的结果，可在不同时间间隔受到各种治疗药物的普遍或选择性影响。大鼠中的RPAR可能在检测治疗RA的新型治疗药物方面具有实用性。
