Wahlig T M, Thompson T R, Sinaiko A R
Division of Neonatology, University of Minnesota Medical School, Minneapolis.
Clin Perinatol. 1992 Mar;19(1):251-63.
In the neonate, there are a number of age-related differences in drug disposition (bioavailability, distribution, metabolism, and excretion), and these are directly related to the degree of prematurity. This article discusses the use of drugs that are commonly administered to the neonatal patient, with special emphasis given to renal considerations. These drugs include diuretics, theophylline, converting enzyme inhibitors, calcium channel blockers, indomethacin, and dopamine.
在新生儿中，药物处置（生物利用度、分布、代谢和排泄）存在一些与年龄相关的差异，这些差异与早产程度直接相关。本文讨论了常用于新生儿患者的药物的使用，特别强调了肾脏方面的考虑。这些药物包括利尿剂、茶碱、血管紧张素转换酶抑制剂、钙通道阻滞剂、吲哚美辛和多巴胺。
