Lanzafame Agata, Bonfiglio Giovanni, Santini Luca, Mattina Roberto
Istituto di Microbiologia, Università di Milano, Milano, Italia.
Chemotherapy. 2005 Mar;51(1):44-50. doi: 10.1159/000084418. Epub 2005 Mar 14.
The objective of our study was to evaluate the in vitro activity of levofloxacin in comparison with other antibiotics (coamoxiclav, ceftriaxone, ceftazidime, meropenem, aztreonam, ciprofloxacin and netilmicin) against about 500 Gram-negative nosocomial microorganisms, isolated during 2003. The bactericidal activities (minimal bactericidal activity and killing curve) of levofloxacin and the other antibiotics were also evaluated. The results confirm the excellent in vitro activity of levofloxacin against multiresistant nosocomial Gram-negative pathogens, including the 73 extended spectrum beta-lactamase producer strains (90% of Escherichia coli, Enterobacter cloacae and Klebsiella pneumoniae were inhibited at 0.5 mg/l). Of particular interest is its susceptibility and bactericidal activity against Stenotrophomonas maltophilia strains. In conclusion, due to the favorable pharmacokinetics and pharmacodynamics of the molecule, associated with its safety, levofloxacin may represent a valid therapeutic option in the treatment of severe Gram-negative nosocomial infections.
我们研究的目的是评估左氧氟沙星与其他抗生素（阿莫西林克拉维酸、头孢曲松、头孢他啶、美罗培南、氨曲南、环丙沙星和奈替米星）相比，对2003年期间分离出的约500株革兰氏阴性医院微生物的体外活性。还评估了左氧氟沙星和其他抗生素的杀菌活性（最小杀菌活性和杀菌曲线）。结果证实左氧氟沙星对多重耐药医院革兰氏阴性病原体具有优异的体外活性，包括73株产超广谱β-内酰胺酶菌株（90%的大肠杆菌、阴沟肠杆菌和肺炎克雷伯菌在0.5mg/l时被抑制）。特别值得关注的是其对嗜麦芽窄食单胞菌菌株的敏感性和杀菌活性。总之，由于该分子有利的药代动力学和药效学特性，以及其安全性，左氧氟沙星可能是治疗严重革兰氏阴性医院感染的有效治疗选择。
