Dashner Roger A, Clark David L, Kangarlu Allahyar, Baudendistel Klaus T, Chakeres Donald W
Division of Anatomy, Ohio State University, Columbus, Ohio, USA.
Clin Anat. 2005 Apr;18(3):164-70. doi: 10.1002/ca.20070.
The purpose of this study was to quantify the spatial resolution of microscopic arteries on magnetic resonance images acquired at 8 Tesla (T). Techniques similar to those used for standard MRI of the human brain in vivo at 8 T were utilized to generate high-resolution gradient echo (GE) images of a whole postmortem human brain whose common carotid arterial system had been injected with an epoxy-resin. Single slice images, along with summed images of up to 5 contiguous slices, were then compared to color digital photographs detailing the distribution of the arterial system on the surface of the same injected brain. There was excellent MR visualization of the microscopic cerebral arteries down to a spatial resolution of 200 microm. Through the use of an 8 T whole-body MRI scanner and standard GE imaging sequences, microscopic arterial structures can be clearly resolved down to a dimension of 200 microm.
本研究的目的是量化在8特斯拉（T）下采集的磁共振图像上微观动脉的空间分辨率。采用与在8T下对活体人类大脑进行标准MRI所用技术相似的技术，生成了一个死后完整人类大脑的高分辨率梯度回波（GE）图像，该大脑的颈总动脉系统已注入环氧树脂。然后将单幅切片图像以及多达5个连续切片的叠加图像与详细显示同一注入大脑表面动脉系统分布的彩色数码照片进行比较。在200微米的空间分辨率下，微观脑动脉具有出色的磁共振可视化效果。通过使用8T全身MRI扫描仪和标准GE成像序列，可以清晰分辨低至200微米尺寸的微观动脉结构。
