Rossi P
Cardiology Department, Ospedale Maggiore, Novara, Italy.
Chest. 1992 May;101(5 Suppl):350S-353S. doi: 10.1378/chest.101.5_supplement.350s.
Multiple compensatory mechanisms operate to preserve exercise tolerance in patients with left ventricular failure. Exercise capacity of most patients with chronic heart failure is limited by dyspnea or fatigue, or both. Maximal stress testing with direct assessment of peak O2 uptake is an essential measurement in planning exercise conditioning programs, which are now attracting patients with chronic heart failure. The biochemical and histologic patterns of skeletal muscle changes seen in chronic heart failure patients are consistent with the effects of long-term exercise deconditioning in normal subjects. Recent studies have suggested beneficial effects of training in subjects with moderate or even severe left ventricular dysfunction by showing increased exercise tolerance or peak O2 consumption, anaerobic threshold, peak leg blood flow, peak central arteriovenous oxygen difference and decreased lactate accumulation. However, a number of questions remain unanswered. Exercise training for the treatment of chronic heart failure should be determined on an individual basis and used with caution.
多种代偿机制发挥作用,以维持左心室衰竭患者的运动耐量。大多数慢性心力衰竭患者的运动能力受到呼吸困难或疲劳,或两者的限制。通过直接评估峰值摄氧量进行的最大应激测试,是制定运动调节计划的一项重要测量方法,目前该计划正吸引着慢性心力衰竭患者。慢性心力衰竭患者骨骼肌变化的生化和组织学模式,与正常受试者长期运动失健的影响一致。最近的研究表明,对中度甚至重度左心室功能障碍的受试者进行训练具有有益效果,表现为运动耐量增加、峰值摄氧量、无氧阈值、腿部峰值血流量、中心动静脉氧分压差峰值增加,以及乳酸积累减少。然而,仍有许多问题未得到解答。治疗慢性心力衰竭的运动训练应因人而异,并谨慎使用。