Zeng G B, Zhang Z X, Xu Y J, Duan S F
Respiratory Research Institute, Tongji Hospital, Tongji Medical University, Wuhan.
Chin Med J (Engl). 1992 Jan;105(1):49-54.
The effect of exercise on pulmonary gas exchange, arterial oxygenation, oxygen transport and delivery, and hemodynamics are studied in 100 patients with chronic obstructive pulmonary diseases. According to the change of PaO2 or PaCO2 induced by exercise, patients were divided into two groups. Group A (n = 52) had significantly increased of PaO2 with little change in PaCO2. Mixed venous PO2, oxygen transport and coefficient of oxygen delivery decreased while the alveolar-arterial PO2 gradients and venous admixture increased significantly in Group B as compared with these parameters in Group A during exercise. Our data imply that exercise may lead to marked deterioration of pulmonary gas exchange, arterial oxygenation, oxygen transport and hemodynamic abnormalities in patients in whom PaO2 is decreased during exercise.
对100例慢性阻塞性肺疾病患者研究了运动对肺气体交换、动脉氧合、氧运输与输送以及血流动力学的影响。根据运动诱发的PaO₂或PaCO₂变化，将患者分为两组。A组（n = 52）PaO₂显著升高，PaCO₂变化不大。与运动期间A组的这些参数相比，B组运动时混合静脉血氧分压、氧运输和氧输送系数降低，而肺泡-动脉血氧分压差和静脉血掺杂显著增加。我们的数据表明，运动可能导致运动期间PaO₂降低的患者肺气体交换、动脉氧合、氧运输和血流动力学异常显著恶化。
