Leng Hong-xia, Liu Wei-ming, Zhu Zhi-guo, Han Li-qin
Jilin Military Medical College, Fourth Military Medical University, Jilin 132013, China.
Guang Pu Xue Yu Guang Pu Fen Xi. 2004 May;24(5):625-7.
Thymopeptide and transfer factor are two common clinic biological preparations, which are used to cure immunodeficiency, low immunofunction or infectious disease caused by virus or fungi owing to their functions of increasing body immunity. In order to discuss the relationship between trace elements and those related diseases, to coordinate sound clinic use of the preparations and to provide productive data on them, atomic absorption spectrophotometry was used to detect the contents of Zn, Cu, Fe, Mn, Co and Ni in thymopeptide and transfer factor biological preparations. Respective contents of detected elements were compared in a statistical way. Results show that Zn and Co contents in thymopeptide were lower than in transfer factor; the contents of Cu, Fe, Mn and Ni, in thymopeptide were higher than in transfer factor. For Zn, Cu, Mn and Co, there was a significant difference between the two biologicam preparations (P<0.01). For Fe and Ni there was a great difference (Q<0.05). The results can provide useful data for sound clinic biological injection to promote immune function, and for increasing or decreasing certain trace elements in preparation.
胸腺肽和转移因子是两种常见的临床生物制剂，因其具有增强机体免疫力的功能，常用于治疗免疫缺陷、免疫功能低下或由病毒或真菌引起的传染病。为探讨微量元素与这些相关疾病的关系，规范临床对这些制剂的合理使用，并提供相关生产数据，采用原子吸收分光光度法检测胸腺肽和转移因子生物制剂中锌、铜、铁、锰、钴和镍的含量。对检测元素的各自含量进行统计学比较。结果显示，胸腺肽中锌和钴的含量低于转移因子；胸腺肽中铜、铁、锰和镍的含量高于转移因子。对于锌、铜、锰和钴，两种生物制剂之间存在显著差异（P<0.01）。对于铁和镍，差异较大（Q<0.05）。这些结果可为促进免疫功能的合理临床生物注射以及制剂中某些微量元素的增减提供有用数据。
