Liu Rui Hai, Liu Jiaren, Chen Bingqing
Department of Food Science, Cornell University, Ithaca, New York 14853-7201, USA.
J Agric Food Chem. 2005 Mar 23;53(6):2341-3. doi: 10.1021/jf058010c.
Regular consumption of fruits and vegetables has been consistently shown to be associated with reduced risk of developing chronic diseases such as cancer and cardiovascular disease. Apples are commonly consumed and are the major contributors of phytochemicals in human diets. It was previously reported that apple extracts exhibit strong antioxidant and antiproliferative activities and that the major part of total antioxidant activity is from the combination of phytochemicals. Phytochemicals, including phenolics and flavonoids, are suggested to be the bioactive compounds contributing to the health benefits of apples. Here it is shown that whole apple extracts prevent mammary cancer in a rat model in a dose-dependent manner at doses comparable to human consumption of one, three, and six apples a day. This study demonstrated that whole apple extracts effectively inhibited mammary cancer growth in the rat model; thus, consumption of apples may be an effective strategy for cancer protection.
长期食用水果和蔬菜一直被证明与降低患癌症和心血管疾病等慢性病的风险有关。苹果是常见的食用水果，也是人类饮食中植物化学物质的主要来源。此前有报道称，苹果提取物具有强大的抗氧化和抗增殖活性，总抗氧化活性的主要部分来自植物化学物质的组合。包括酚类和黄酮类在内的植物化学物质被认为是赋予苹果健康益处的生物活性化合物。本文表明，在与人类每天食用1个、3个和6个苹果相当的剂量下，全苹果提取物能以剂量依赖的方式预防大鼠模型中的乳腺癌。这项研究表明，全苹果提取物能有效抑制大鼠模型中的乳腺癌生长；因此，食用苹果可能是一种有效的癌症预防策略。
