抗心律失常药物使犬心室除颤阈值升高。

Elevation of ventricular defibrillation threshold in dogs by antiarrhythmic drugs.

作者信息

Babbs C F, Yim G K, Whistler S J, Tacker W A, Geddes L A

出版信息

Am Heart J. 1979 Sep;98(3):345-50. doi: 10.1016/0002-8703(79)90047-4.

Abstract

Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhytmic drugs tested. Bolus injections produced a transient rise and continuous infusions produced a steady rise in difibrillation threshold. The maximal percent elevations in mean defibrillation threshold during the 60 minutes after intravenous drug treatment in groups of n = 5 dogs were: (formula: see text). Accordingly, individuals receiving antiarrhythmic drugs who nonetheless fibrillate may require greater electric shock strength for defibrillation.

摘要

在25只戊巴比妥麻醉的犬中，研究了抗心律失常药物对经阻尼正弦电击进行心室除颤的阈下传递能量（TDE）和阈峰值电流（TPC）的影响。所测试的三种抗心律失常药物均使TDE和TPC升高。推注产生短暂升高，持续输注使除颤阈值持续升高。在每组n = 5只犬静脉药物治疗后60分钟内，平均除颤阈值的最大升高百分比为：（公式：见原文）。因此，接受抗心律失常药物治疗但仍发生颤动的个体可能需要更强的电击强度来进行除颤。