Tacker W A, Niebauer M J, Babbs C F, Combs W J, Hahn B M, Barker M A, Seipel J F, Bourland J D, Geddes L A
Crit Care Med. 1980 Mar;8(3):177-80. doi: 10.1097/00003246-198003000-00018.
This study was conducted to determine the effects of clofilium phosphate and bretylium tosylate on ventricular defibrillation threshold. Dogs were anesthetized with pentobarbital and subjected to repeated fibrillation-defibrillation episodes. Defibrillation thresholds were determined at 15-min intervals, using underdamped 5--6 msec sinusoidal current shocks, from 30 min before drug injection to 120 min after injection. Eight dogs were given clofilium phosphate (0.34 mg/kg, iv). Another 10 dogs were given bretylium tosylate (10.0 mg/kg, iv). Both drugs lowered defibrillation threshold from 15--90 min after injection. The maximum clofilium effect was a 31% decrease in threshold current and a 54% decrease in threshold energy. The greatest decrease in defibrillation threshold produced by bretylium was 16% for current and 31% for energy. These drug induced changes in defibrillation threshold are of potential clinical benefit if they occur in human subjects at doses which are effective for control of ventricular arrhythmias.
本研究旨在确定磷酸氯喹和甲苯磺酸溴苄铵对心室颤动阈值的影响。用戊巴比妥麻醉犬，并使其经历反复的颤动-除颤发作。从注射药物前30分钟至注射后120分钟，每隔15分钟使用欠阻尼5 - 6毫秒正弦电流电击测定除颤阈值。8只犬静脉注射磷酸氯喹（0.34毫克/千克）。另外10只犬静脉注射甲苯磺酸溴苄铵（10.0毫克/千克）。两种药物在注射后15 - 90分钟均降低了除颤阈值。磷酸氯喹的最大作用是阈值电流降低31%，阈值能量降低54%。溴苄铵引起的除颤阈值最大降低为电流降低16%，能量降低31%。如果这些药物在人体中以有效控制室性心律失常的剂量出现，那么它们引起的除颤阈值变化可能具有临床益处。
