Zhou Yi-Biao, Jiang Qing-Wu, Zhao Gen-Ming
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Dec;25(12):1024-7.
To study the effect of infection control on schistosomasis Japonicum based on selective chemotherapy.
Data were derived from national surveillance of schistosomiasis from 2000 to 2002, and random effect model of Meta-analysis was used to analyze the effect of chemotherapy on controlling schistosomiasis infection.
One year after chemotherapy was started in the pilot villages where infection rate of schistosomiasis was more than 10%, the infection rates among residents and eggs per gram (EPG) of patients as well as population (geometric mean, GM) significantly reduced by 20.15%, 22.91% and 33.93% with 95% confidence interval (CI) 6.95 - 31.48, 14.69 - 30.34 and 11.69 - 50.68 respectively. In the pilot villages where infection rates were between 6% and 10%, the control measures largely base on chemotherapy significantly reduced the infection rate, by 24.50 (95% CI: 5.35 - 39.83). However the infection rates were no longer reduced in the pilot villages where the infection rate was less than 6%; EPG of patients and residents were maintained at the original level in the pilot villages where infection rate was 10% or less.
In China, the rates of schistosomiasis Japonicum infection could be effectively reduced through the control measures largely based on chemotherapy, and they were kept at a relatively low level. However, it was very difficult to interrupt the transmission of schistosomiasis.
基于选择性化疗研究感染控制对日本血吸虫病的影响。
数据来源于2000年至2002年全国血吸虫病监测，采用Meta分析的随机效应模型分析化疗对控制血吸虫病感染的效果。
在血吸虫病感染率超过10%的试点村庄开始化疗一年后，居民感染率、患者每克粪便虫卵数（EPG）以及人群（几何均数，GM）分别显著降低了20.15%、22.91%和33.93%，95%置信区间（CI）分别为6.95 - 31.48、14.69 - 30.34和11.69 - 50.68。在感染率为6%至10%的试点村庄，以化疗为主的控制措施显著降低了感染率，降低了24.50（95%CI：5.35 - 39.83）。然而，在感染率低于6%的试点村庄，感染率不再降低；在感染率为10%及以下的试点村庄，患者和居民的EPG维持在原有水平。
在中国，通过以化疗为主的控制措施可有效降低日本血吸虫病感染率，并将其维持在较低水平。然而，要阻断血吸虫病的传播非常困难。
