Guo Jiagang, Li Yuesheng, Gray Darren, Ning An, Hu Guanghan, Chen Honggen, Davis George M, Sleigh Adrian C, Feng Zheng, McManus Donald P, Williams Gail M
Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People's Republic of China.
Am J Trop Med Hyg. 2006 Feb;74(2):335-41.
Schistosomiasis japonica is a zoonosis of major public health importance in southern China. We undertook a drug intervention to test the hypothesis that buffalo are major reservoirs for human infection in the marshlands/lake areas, where one million people are infected. We compared human and buffalo infection rates and intensity in an intervention village (Jishan), where humans and buffalo were treated with praziquantel, and a control village (Hexi), where only humans were treated, in the Poyang Lake region. Over the four-year study, human incidence in Jishan decreased but increased in Hexi. Adjustment of incidence by age, sex, water exposure, year, and village further confirmed the decreased human infection in Jishan. Chemotherapy for buffaloes resulted in a decrease in buffalo infection rates in Jishan, which coincided with the reduction in human infection rates there in the last two years of the study. Mathematical modeling predicted that buffalo are responsible for 75% of human transmission in Jishan.
日本血吸虫病是中国南方一种具有重大公共卫生意义的人畜共患病。我们进行了一项药物干预试验，以验证以下假设：在有100万人感染的沼泽地/湖区，水牛是人类感染的主要传染源。我们比较了鄱阳湖地区一个干预村（吉山）和一个对照村（河西）的人和水牛的感染率及感染强度。在干预村，人和水牛都接受了吡喹酮治疗；在对照村，仅对人进行了治疗。在为期四年的研究中，吉山的人类感染发病率下降，而河西的发病率上升。按年龄、性别、接触水的情况、年份和村庄对发病率进行调整后，进一步证实了吉山人类感染率的下降。对水牛进行化疗后，吉山水牛的感染率下降，这与研究最后两年该地区人类感染率的降低相吻合。数学模型预测，在吉山，75%的人类感染是由水牛传播的。
