一种结合人绒毛膜促性腺激素但不结合人促黄体生成素的细菌结合位点。
A bacterial binding site which binds human chorionic gonadotropin but not human luteinizing hormone.
作者信息
Carrell D T, Odell W D
机构信息
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
出版信息
Endocr Res. 1992;18(1):51-8. doi: 10.3109/07435809209035928.
Exposed sites on Pseudomonas maltophilia (ATC #1637), which bind both human chorionic gonadotropin (hCG) and a native hCG-like ligand with equal high affinity, are described. This high-affinity binding site (Kd = 1.3 x 10(-10) binds hCG, but does not bind human luteinizing hormone (hLH), nor related human glycoprotein hormones, thyrotropin, and follicle stimulating hormone. A lower affinity, 2.3 x 10(-9), is also described which binds hLH and hCG equally well. This is the first description of a high-affinity binding site in nature, which distinguishes hCG from hLH.
嗜麦芽窄食单胞菌（ATC编号#1637）上存在一些暴露位点，这些位点能以同等高亲和力结合人绒毛膜促性腺激素（hCG）和一种天然的hCG样配体。描述了这种高亲和力结合位点（解离常数Kd = 1.3×10⁻¹⁰），它能结合hCG，但不结合人促黄体生成素（hLH），也不结合相关的人糖蛋白激素、促甲状腺激素和促卵泡激素。还描述了一种较低亲和力（2.3×10⁻⁹）的位点，它对hLH和hCG的结合能力相当。这是自然界中高亲和力结合位点的首次描述，该位点可区分hCG和hLH。
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