Carrell D T, Odell W D
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
Endocr Res. 1992;18(1):51-8. doi: 10.3109/07435809209035928.
Exposed sites on Pseudomonas maltophilia (ATC #1637), which bind both human chorionic gonadotropin (hCG) and a native hCG-like ligand with equal high affinity, are described. This high-affinity binding site (Kd = 1.3 x 10(-10) binds hCG, but does not bind human luteinizing hormone (hLH), nor related human glycoprotein hormones, thyrotropin, and follicle stimulating hormone. A lower affinity, 2.3 x 10(-9), is also described which binds hLH and hCG equally well. This is the first description of a high-affinity binding site in nature, which distinguishes hCG from hLH.
嗜麦芽窄食单胞菌（ATC编号#1637）上存在一些暴露位点，这些位点能以同等高亲和力结合人绒毛膜促性腺激素（hCG）和一种天然的hCG样配体。描述了这种高亲和力结合位点（解离常数Kd = 1.3×10⁻¹⁰），它能结合hCG，但不结合人促黄体生成素（hLH），也不结合相关的人糖蛋白激素、促甲状腺激素和促卵泡激素。还描述了一种较低亲和力（2.3×10⁻⁹）的位点，它对hLH和hCG的结合能力相当。这是自然界中高亲和力结合位点的首次描述，该位点可区分hCG和hLH。
