Extraosseous accumulation of (99m)Tc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma.
作者信息
Abe Koichiro, Sasaki Masayuki, Kuwabara Yasuo, Koga Hirofumi, Baba Shingo, Kaneko Koichiro, Hayashi Kazutaka, Shioyama Yoshiyuki, Tajiri Tatsuro, Suita Sachiyo, Honda Hiroshi
机构信息
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Japan.
出版信息
Ann Nucl Med. 2005 Feb;19(1):35-40. doi: 10.1007/BF02986333.
OBJECTIVE
The aim of this study is to clarify the period of extraosseous accumulation of (99m)Tc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region.
METHODS
We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent (99m)Tc-HMDP bone scintigraphies periodically before and after radiation therapy.
RESULTS
Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from 0 to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of (99m)Tc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy.
CONCLUSION
When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.
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